TAURODEOXYCHOLIC ACID ALLEVIATES DIQUAT-INDUCED INTESTINAL BARRIER FUNCTION INJURY IN MICE THROUGH THE UPREGULATION OF NRF2-MEDIATED SIGNALING PATHWAY

Taurodeoxycholic acid alleviates diquat-induced intestinal barrier function injury in mice through the upregulation of Nrf2-mediated signaling pathway

Abstract Oxidative stress is an important contributor to gastrointestinal diseases in multiple ways.Taurodeoxycholic acid (TDCA) is a metabolite of bile acids and has anti-inflammatory and protective effects on the intestinal tract.However, whether TDCA can alleviate oxidative stress in the intestine is still unclear.Here, we BODY BALM investigated

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The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias

Abstract Background Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs).Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias trial results.Metho

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Comparative transcriptomics of Gymnosporangium spp. teliospores reveals a conserved genetic program at this specific stage of the rust fungal life cycle

Abstract Background Gymnosporangium spp.are fungal plant pathogens causing rust disease and most of them are known to infect two different host plants (heteroecious) with four spore stages (demicyclic).In the present study, we sequenced the transcriptome of G.japonicum teliospores on its host Classic Cap Box plant Juniperus chinensis and we perform

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